La Kiss Note es un poderoso cuaderno con el poder de hacer que cualquier persona cuyo nombre este escrito junto a otro en ella, instantáneamente se enamoren y besen sin importar cualquier circunstancia. Este elemento mágico pertenece a un ángel llamada Guri, cuyo trabajo como cupido es formar parejas. Sin embargo, accidentalmente escribe el nombre de Seiji Aino, un estudiante de secundaria regular, y a menos que Seiji bese a alguien, Guri morirá. Guri convence a Seiji de besar a Akane Hiyama, la chica más popular de la escuela. Sin embargo, resulta que Akane tiene sentimientos aún más fuertes por él, bordeando lo obsesivo y psicótico. Eventualmente, Akane y Seiji comienzan a salir, pero no antes de que Guri decida que también tiene sentimientos por Seiji. Esto hace que se convierta en un infierno para Seiji, quien sólo quiere una relación normal con las chicas.

Aino Seiji, a typical male high school student, meets Guri, who is... ashinigami? No, a pervert--no! An angel?! Guri introduces him to the Kiss Note and explains that if he doesn't kiss someone within 24 hours, she will die. So it's off to Seiji's school to find his school crush, his classmate, Hiyama Akane, but of course nothing is ever so simple...

During Yuzu's daily routine of stalking through her sister, Akane's trash, Guri suddenly appears and the two girls begin taking love consultations at school. Seiji and Akane reluctantly agree to help look for coupling candidates and soon the group thinks they have found a pair of ideal targets. However, things get much more complicated when no one can agree if the intended couple really share each other's feelings. In the midst of all this Yuzu and Guri scheme an elaborate plan to prove their instincts are right.

Guri finally meets Seiji's younger sister, Akua and is surprised by her rather cold attitude towards her big brother. The cupid decides to learn more about what changed this once loving sister, and Yuzu is right there to help (or make things worse...). But while the girls are getting acquainted the demon Stolas appears and a panick ensues! The strangely psychotic penguin seems to have a special affinity for Akua and sends her running. It's up to her big brother Seiji to save her like he used to.

Despite harsh words from Akane, Yuzu will go to great lengths for her beloved older sister. Yuzu refuses to relinquish her forbidden love even for someone like Seiji, who she may care about more than she realizes. Meanwhile, on the hunt for a new couple to match, fortune smiles upon Seiji and Guri when a classmate approaches them saying she has a crush she would like paired with.

Struggling to find Seiji, Akane and Yuzu are worried when Guri tells them that he is off with Shikimi searching for her crush. The concern is warranted when Seiji finds himself in the midst of a torture session! Her ultimate goal isn't just Seiji, but Akane and Yuzu. What is her link to the two sisters and what is it that she's after?

Summer vacation! Seiji, Guri, Akane and Yuzu have invited Akua to go with them to the beach. Akane tries to get Akua to go swimming with her in attempt to get closer to Seiji's little sister, but Akua gives her the cold shoulder. Pouting at her brother and his harem Akua goes to swim by herself but a dark shadow looms beneath her. Meanwhile, summer also means tests of courage! Guri suddenly invites Seiji, Akane, and Yuzu to the school after dark for a test of courage but her real motives are to pair another young couple who have asked for her help. Seiji thinks something isn't quite right about the pair though...

After an argument with Seiji, Guri goes wandering the city on her own. During a stop at the bookstore for the latest volume from her favorite manga artist, a handsome stranger stops to talk to her. When the unknown young man invites Guri out on a date she can't bring herself to refuse. Getting to experience a date with someone other than Seiji seemed like a good idea but Guri can't help be feel something isn't quite right. Meanwhile, things have gotten more complicated in Akane's family and she's suddenly under house-arrest!

Yuzu and Guri are off to save Akane! Several obstacles are placed in their path but the girls overcome them with ease, only to find that Akane is not herself. A happy reunion quickly turns to shock as Akane turns her blade on her sister. Yuzu tries desperately to reach her beloved sister but nothing seems to get through. When Seiji finally appears Akane's love is put to the test, will she do as her mother commands and get rid of Seiji once and for all?

It's time for the school cultural festival! Excitement is in the air as life seems to be back to normal for Seiji, Akane, and the rest, but all is not what it seems. Shikimi suddenly has transferred into Seiji's class and it now has Akane on edge. When its decided that their class will be putting on a play with Shikimi in the leading role of the princess Akane is roped into playing the prince while Guri gets to play the rival pirate to the prince. On top of all this even Yuzu has started acting strangely and Seiji finds himself stuck in the middle, as always.